Melatonin helps regulate other hormones and maintains the body's circadian rhythm. The circadian rhythm is an internal timing mechanism that plays a critical role in when we fall asleep and when we wake up.
Curcumin can inhibit many molecules known to play major roles in inflammation. Curcumin blocks NF-kB, a molecule that travels into the nuclei of cells and turns on genes related to inflammation. NF-kB is believed to play a major role in many chronic diseases.